GIP K-cell identity
Gene co-expression module in Enteroendocrine cells
| Category | k cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 17 of 18 genes have a known function matching the annotation |
Why this annotation
The module is centered on GIP (715x) and GATA4, the transcription factor that specifies proximal K cells, and every member peaks in K cells. This makes it a genuine K-cell transcriptional state; only HLA-DPB1 looks like dendritic-cell carry-over.
Genes
Most correlated modules
- N/K villus program · correlation 0.60
- DAG/PKC signaling · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.