SCUBA

Enteroendocrine cells: gene co-expression modules

Scattered hormone-secreting epithelial cells of the small intestine and colon; sensing nutrients and microbial metabolites, they release serotonin, GLP-1, CCK, GIP and somatostatin to steer digestion and appetite.

SCUBA's reference network for Enteroendocrine cells holds 105 gene modules covering 1,518 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

chromatin regulation & transcription (1)

Posterior HOX code · 0 genes

Cytoskeletal (2)

Ciliary axoneme genes · 0 genes
L-cell Ciliary Genes · 0 genes

d cell program (4)

EEC development (25)

ARX+ Peptidergic Lineage · 0 genes
BAIAP3/CHCHD6 immature axis · 0 genes
BMP/SMAD target genes · 0 genes
CDKN1C cycle-exit progenitor · 0 genes
CDX2/HNF4G intestinal identity · 0 genes
Chaperonin/MYC growth genes · 0 genes
Crypt-positioned EEC state · 0 genes
D/L-cell lineage signature · 0 genes
ELAVL4 post-transcriptional axis · 0 genes
FGFRL1/VWC2 pre-EEC state · 0 genes
Goblet-like secretory progenitor · 0 genes
HES6 progenitor commitment · 0 genes
LGR5/NUMBL immature state · 0 genes
LMX1B/OR51E1 EC-primed precursor · 0 genes
NEUROG3+ endocrine progenitor · 0 genes
PAX4/NKX2-2 specification · 0 genes
Peptidergic branch genes · 0 genes
Peptidergic neuronal-type genes · 0 genes
Proximal MX/I-cell signature · 0 genes
Proximal regional identity · 0 genes
RARRES1/PCSK5 small-bowel program · 0 genes
SMOC2/FOXA2 crypt state · 0 genes
SOX4/MEX3A pre-EEC regulators · 0 genes
TAC1/RPRML small-bowel EEC · 0 genes
WNT9A/L1TD1 pre-EEC state · 0 genes

Enterochromaffin program (30)

ADRA1B/SYNGR4 EC subset · 0 genes
CALCR/CDHR3 EC program · 0 genes
CASR/GIRK membrane sensing · 0 genes
CDH22/SPATA17 EC markers · 0 genes
CES1/TRPC7 EC subset · 0 genes
EC accessory genes · 0 genes
EC Calcium-Triggered Exocytosis · 0 genes
EC membrane receptors · 0 genes
EC Neuronal Excitability · 0 genes
FHL1/SCN8A EC state · 0 genes
GATA2/SMAD6 regulators · 0 genes
GREM2/CDH26 EC subset · 0 genes
GULP1/PRDM16 EC genes · 0 genes
LMX1A/VMAT1 EC identity · 0 genes
Minor EC sub-state · 0 genes
NAT8L/APOD EC subset · 0 genes
Neuron-like excitability · 0 genes
RXFP4+ EC signature · 0 genes
SCN3A/HCN1 EC excitability · 0 genes
Sensory GPCR/cadherin · 0 genes
Serotonergic EC specification · 0 genes
Serotonin biosynthesis · 0 genes
SV2C/KCNS3 EC program · 0 genes
Synaptic scaffold/regulators · 0 genes
SYT1/ATP6V1C2 vesicle genes · 0 genes
SYT4+ vesicle state · 0 genes
TF-defined EC subtype · 0 genes
TRPA1/ADH4 chemosensory EC · 0 genes
TRPM3/KCNIP1 EC signaling · 0 genes
Villus EC subpopulation · 0 genes

Glucose homeostasis (1)

Beta-cell-like glucose sensing · 0 genes

Housekeeping (2)

Abundant housekeeping transcripts · 0 genes
Biosynthetic housekeeping machinery · 0 genes

Hunger regulation (1)

Ghrelin/Motilin M/X-cell · 0 genes

I cell program (7)

CLU/PDZK1 I-cell program · 0 genes
I-cell identity signature · 0 genes
Secretin/epithelial co-program · 0 genes
Small-intestinal absorptive signature · 0 genes
Small-intestinal I/K-cell signature · 0 genes
Small-intestinal Nutrient Sensing · 0 genes
Villus enterocyte-like state · 0 genes

k cell program (3)

l cell program (15)

Colonic INSL5+ L-cell · 0 genes
Colonic L-cell identity · 0 genes
ELR+ chemokine secretion · 0 genes
FFAR4 lipid sensing · 0 genes
GLP-1/PYY hormone program · 0 genes
INSL5 ENaC/ALK subtype · 0 genes
INSL5/N-cell epithelial state · 0 genes
L-cell Accessory Program · 0 genes
L-cell AVPR1B/TMEM236 signature · 0 genes
L-cell identity program · 0 genes
L-cell receptor/adhesion program · 0 genes
L-cell VSTM2A program · 0 genes
L/D-cell excitability genes · 0 genes
SCFA/neuropod sensing · 0 genes
Surface hypoxic state · 0 genes

Metabolic regulation (3)

Small-intestinal lipid metabolism · 0 genes
Small-intestinal nutrient metabolism · 0 genes
TMC5/ACSL5 epithelial axis · 0 genes

migration & adhesion (2)

CADM1/ANK2 adhesion axis · 0 genes
Rho-GEF cytoskeletal signaling · 0 genes

Mitochondrial & OxPhos (1)

Respiratory chain subunits · 0 genes

n cell program (3)

RNA processing & translation (2)

Progenitor hnRNP program · 0 genes
Ribosome/translation machinery · 0 genes

Secretion (3)