DAG/PKC signaling
Gene co-expression module in Enteroendocrine cells
| Category | k cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes are sharply localized to K and D cells, strongest in K cells: ASIC5 24x K/19x D, DGKG 10x K, PTPRT 6x K. Together they mark a shared proximal K/D identity with diacylglycerol/PKC signalling components. Subset restriction rules out contamination despite the enterocyte-typical flags.
Genes
Most correlated modules
- KATP/hormone-receptor sensing · correlation 0.75
- Beta-cell-like glucose sensing · correlation 0.70
- Synaptic adhesion genes · correlation 0.68
- RORB/ECM guidance genes · correlation 0.67
- CLU/PDZK1 I-cell program · correlation 0.67
- Peptidergic branch genes · correlation 0.58
- SST/HHEX lineage identity · correlation 0.57
- GIP K-cell identity · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.