N/K villus program
Gene co-expression module in Enteroendocrine cells
| Category | n cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
The module is sharply localized to N and K cells, with weaker I-cell expression. Its hubs mark mature small-intestinal hormone cells: SIGLEC15, TMEM139, the granule zinc transporter SLC30A8 and TOX2, with SIGLEC15 and TOX2 peaking in N cells. Co-expressed MGAM and CPM likely reflect a shared villus or maturation state of these subsets, because their expression is subset-restricted rather than spread.
Genes
Most correlated modules
- RARRES1/PCSK5 small-bowel program · correlation 0.72
- Neurotensin N-cell Program · correlation 0.68
- Small-intestinal Nutrient Sensing · correlation 0.67
- Small-intestinal I/K-cell signature · correlation 0.66
- GIP K-cell identity · correlation 0.60
- Peptidergic Secretory Granule · correlation 0.55
- NPW terminal maturation · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.