Oxidative Inflammatory Stress
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
TIMP1 is a metalloprotease inhibitor strongly induced in mucosal inflammation and stress. GLRX (glutaredoxin) and SOD3 (extracellular superoxide dismutase) are redox defense enzymes. PDZK1IP1 (MAP17) is upregulated under oxidative stress and in inflamed epithelium. FXYD5 (dysadherin) is induced by inflammation and reduces cell-cell adhesion. ANXA3/4/5 are stress-responsive annexins. ZG16B is a goblet/secretory cell marker suggesting partial secretory identity. DMKN (dermokine) is expressed in differentiating epithelial cells. KDELR3 supports ER protein retention under stress. SRD5A3 is involved in glycosylation and ER function. The strong UC inflammation signal with remission reversal and the redox/stress gene complement point to an oxidative/inflammatory stress response in epithelial progenitors.
Genes
Most correlated modules
- Hypoxia Response · correlation 0.83
- MHC-I Antigen Presentation · correlation 0.80
- Regenerative Epithelial · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.