Hypoxia Response
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub gene HIF1A is the master transcription factor of the hypoxic response. Supporting genes include ERO1A (a direct HIF1A transcriptional target involved in ER oxidative folding under hypoxia), ADAM9 (metalloprotease upregulated by hypoxia), CEACAM5 (hypoxia-induced epithelial antigen), JAK1 (cytokine/hypoxia crosstalk), and IFITM2. The module is strongly upregulated in UC and CD inflammation and reverses in remission, consistent with epithelial hypoxia in inflamed mucosa. BACE2 and CTTN are also regulated in hypoxic contexts. Neighbor M78 contains HK2 (glycolysis, HIF1A target), reinforcing a hypoxia-metabolic neighborhood.
Genes
Most correlated modules
- ER Stress UPR · correlation 0.84
- Oxidative Inflammatory Stress · correlation 0.83
- MHC-I Antigen Presentation · correlation 0.83
- Inflammatory Lipid Stress · correlation 0.81
- Cytoskeletal Junction · correlation 0.78
- Epithelial Barrier Innate Immunity · correlation 0.75
- Glycolytic Barrier Stress · correlation 0.72
- IFN-gamma Response · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.