MHC-I Antigen Presentation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes HLA-A/B/C and B2M define MHC class I antigen presentation. PSMB8 (immunoproteasome beta subunit), PSME1/2 (PA28 proteasome activator complex) are core components of the IFN-γ-induced antigen processing machinery. IFITM3 is a canonical interferon-stimulated gene. CASP1 and TNFSF10 add inflammasome and apoptotic signaling. GPX2 reflects oxidative stress co-occurring with inflammation. Strong upregulation in both UC and CD inflammation with reversal in UC remission confirms an IFN-driven antigen presentation program in inflamed epithelium.
Genes
Most correlated modules
- Hypoxia Response · correlation 0.83
- Oxidative Inflammatory Stress · correlation 0.80
- ER Stress UPR · correlation 0.78
- MHC-II Antigen Presentation · correlation 0.78
- Inflammatory Lipid Stress · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.