MYB Progenitor Transcription
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
MYB is a key transcription factor driving intestinal progenitor proliferation and is essential for transit-amplifying cell maintenance. CCND2 (Cyclin D2) drives G1/S cell cycle progression. SMARCC1 is a core SWI/SNF chromatin remodeling complex subunit. NFIA is a transcription factor involved in progenitor identity. ZBTB20 and MLXIP are transcriptional regulators. FERMT1 (Kindlin-1) regulates integrin-mediated adhesion in epithelial cells. NRIP1 is a nuclear receptor coactivator. ZKSCAN1 is a KRAB zinc finger transcription factor. The module represents a chromatin remodeling and transcriptional regulatory program associated with progenitor proliferation, centered on MYB. Mildly increased in CD inflammation and with treatment, suggesting modest inflammatory modulation of this proliferative transcriptional state.
Genes
Most correlated modules
- WNT Progenitor Quiescence · correlation 0.87
- Progenitor Eph Activation · correlation 0.86
- Intestinal Stem Cell Identity · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.