Progenitor Eph Activation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub genes include SLC12A2 (ion cotransporter expressed in proliferating crypts), EPHB2 (canonical WNT target and crypt progenitor marker for crypt-villus positioning), LRIG1 (intestinal stem/progenitor marker and EGFR negative regulator), ENAH (actin dynamics, migration), PIK3R1 (PI3K signaling), and TRAF5 (TNF receptor-associated signaling). EPHB2 and LRIG1 are well-established intestinal progenitor identity markers. The module is significantly upregulated in UC inflammation, suggesting reactive progenitor activation. As a neighbor to M71 (ASCL2+ ISC) and M83 (WNT-quiescence), this module likely represents a more activated/proliferative progenitor state with WNT-Eph axis activity.
Genes
Most correlated modules
- WNT Progenitor Quiescence · correlation 0.89
- MYB Progenitor Transcription · correlation 0.86
- LGR5+ Stem Cell · correlation 0.77
- Intestinal Stem Cell Identity · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.