WNT Progenitor Quiescence
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | WNT pathway |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include ZNRF3 (WNT pathway E3 ligase/negative regulator), PTK7 (non-canonical WNT receptor), FOXO3 (quiescence/stemness TF), CDK6 (G1 cell cycle kinase), ALDH1B1 (stem cell aldehyde dehydrogenase marker), SGK3 (PI3K-downstream kinase), DAB2 (TGF-β/endocytosis adaptor), and ARID5B (chromatin TF). The module is decreased in CD inflammation and increased in remission, consistent with a WNT-modulated progenitor quiescence program that is suppressed during active disease. RUBCNL (autophagy-related), MAP3K20 (stress MAPK), and SORBS1 (cytoskeletal) are peripheral members. The dominant theme is WNT pathway modulation in progenitor cells, with ZNRF3 and PTK7 as WNT-specific anchors.
Genes
Most correlated modules
- Progenitor Eph Activation · correlation 0.89
- MYB Progenitor Transcription · correlation 0.87
- Intestinal Stem Cell Identity · correlation 0.85
- LGR5+ Stem Cell · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.