Nuclear Housekeeping
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include NUDT21 (mRNA cleavage/polyadenylation), PARP1 (DNA repair), ATIC and PAICS (de novo purine biosynthesis), NAP1L1 (histone chaperone/nucleosome assembly), CBX5 (HP1α heterochromatin), NONO (nuclear paraspeckle), SMC1A (cohesin), and proteasome components PSMG1/PSMD14. These collectively represent core nuclear housekeeping functions: DNA repair, chromatin maintenance, purine biosynthesis, and nuclear RNA processing. Uniform expression across subsets and moderate-strong memberships support a broad housekeeping identity. Decreased in CD inflammation and restored with treatment is consistent with suppression of basal maintenance programs during active disease.
Genes
Most correlated modules
- TRiC Chaperonin Complex · correlation 0.89
- Chromatin RNA Processing · correlation 0.86
- Housekeeping Transcription · correlation 0.86
- RNA Processing Translation · correlation 0.85
- Nuclear RNA Transport · correlation 0.84
- Actin Cytoskeletal Dynamics · correlation 0.84
- Nuclear Architecture · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.