Tubulin Cytoskeletal
Gene co-expression module in Microfold-like cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes TUBB (beta-tubulin, cytoskeleton), TUBA1C (alpha-tubulin, cytoskeleton), AGPAT2 (lysophosphatidic acid acyltransferase, lipid metabolism), RHOC (Rho GTPase, actin/cytoskeleton/migration), PRSS3 (trypsinogen/serine protease), PI3 (elafin/protease inhibitor), TMEM54 (transmembrane), ETHE1 (persulfide dioxygenase, sulfur metabolism). The two top hub genes are tubulins, and RHOC is a key cytoskeletal regulator. AGPAT2 links to membrane lipid remodeling. The module is mildly downregulated in CD inflammation. The dominant theme is cytoskeletal organization (TUBB, TUBA1C, RHOC) with supporting membrane/lipid components. This is consistent with a cytoskeletal/motility program in M-like cells, potentially related to macrophage migration or shape change.
Genes
Most correlated modules
- Epithelial Metabolic Housekeeping · correlation 0.98
- Inflammatory Activation Stress · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.