Epithelial Metabolic Housekeeping
Gene co-expression module in Microfold-like cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
AP2S1 (clathrin-associated adaptor protein 2 sigma, endocytic trafficking), TXNDC17 (thioredoxin domain-containing, redox homeostasis), CKB (creatine kinase B, cytosolic energy buffering), GMDS (GDP-mannose 4,6-dehydratase, fucose biosynthesis/glycosylation), PRELID1 (mitochondrial lipid transfer, cardiolipin metabolism), PSME2 (proteasome activator PA28 beta, antigen processing), CD24 (epithelial surface marker), TMEM167A (vesicle trafficking). The module combines epithelial metabolic housekeeping functions including redox, glycosylation, energy metabolism, and vesicle trafficking. CD24 anchors epithelial identity.
Genes
Most correlated modules
- Colonocyte Differentiation · correlation 0.99
- ER Protein Folding · correlation 0.99
- Metabolic Detoxification · correlation 0.99
- Oxidative Phosphorylation · correlation 0.99
- Proteasome Proteolysis · correlation 0.98
- ER Protein Homeostasis · correlation 0.98
- OxPhos & Mitochondrial · correlation 0.98
- Epithelial Identity · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.