Microfold-like cells: gene co-expression modules

Specialised follicle-associated epithelial cells with sparse microvilli; they transcytose luminal antigens and microbes to underlying lymphoid tissue, initiating mucosal IgA responses and immune surveillance.

SCUBA's reference network for Microfold-like cells holds 109 gene modules covering 1,231 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Microfold-like cells network in SCUBA

absorptive cell development (7)

• Absorptive Colonocyte Identity · 0 genes
• Absorptive Enterocyte · 0 genes
• Colonocyte Differentiation · 0 genes
• Colonocyte Differentiation · 0 genes
• Colonocyte Epithelial · 0 genes
• Colonocyte Lipid Ion Transport · 0 genes
• Mature Colonocyte Identity · 0 genes

Antigen handling (4)

• Antigen Presentation Housekeeping · 0 genes
• Complement Macrophage Activation · 0 genes
• Interferon Antigen Processing · 0 genes
• Phagocytic Lipid Catabolism · 0 genes

Cell cycle (2)

• Colonocyte Proliferative Recovery · 0 genes
• Epithelial Proliferation · 0 genes

chromatin regulation & transcription (3)

• Chromatin Stress Recovery · 0 genes
• DNA Damage Response · 0 genes
• Macrophage Transcriptional Regulation · 0 genes

Cytoskeletal (6)

• Actin & Membrane · 0 genes
• Actin Cytoskeletal Dynamics · 0 genes
• Actin Cytoskeletal Regulation · 0 genes
• Colonocyte Apical Cytoskeleton · 0 genes
• Cytoskeletal Contractility · 0 genes
• Tubulin Cytoskeletal · 0 genes

Epithelial cell development (1)

• Epithelial Wound Healing · 0 genes

Housekeeping (26)

• Autophagy Lysosomal · 0 genes
• Cellular Homeostasis · 0 genes
• Endosomal Vesicle Trafficking · 0 genes
• Epithelial Identity · 0 genes
• Epithelial Metabolic Housekeeping · 0 genes
• ER & Mitochondrial Maintenance · 0 genes
• Housekeeping Metabolism · 0 genes
• Housekeeping Mixed · 0 genes
• Housekeeping Mixed · 0 genes
• Intracellular Cargo Transport · 0 genes
• Lysosomal Lipid Catabolism · 0 genes
• Macrophage Homeostasis · 0 genes
• Macrophage Homeostasis · 0 genes
• Macrophage Phagocytic · 0 genes
• Membrane Remodeling mTOR · 0 genes
• Membrane Trafficking · 0 genes
• Metabolic Detoxification · 0 genes
• Metabolic Homeostasis · 0 genes
• Metabolic Housekeeping · 0 genes
• Metabolic Housekeeping · 0 genes
• Metabolic Housekeeping · 0 genes
• Organelle Homeostasis · 0 genes
• Proteasome Proteolysis · 0 genes
• Protein Homeostasis · 0 genes
• Sphingolipid Membrane Organization · 0 genes
• Vesicle Membrane Trafficking · 0 genes

Inflammatory (12)

• IL1B Inflammatory Macrophage · 0 genes
• Inflammatory Activation Stress · 0 genes
• Inflammatory Lipid Metabolism · 0 genes
• Inflammatory Myeloid · 0 genes
• Interferon Chemokine Response · 0 genes
• Lipid Mediator Signaling · 0 genes
• Macrophage Oxidative Complement · 0 genes
• NF-κB Inflammatory Activation · 0 genes
• NF-κB Inflammatory Response · 0 genes
• Non-canonical NF-κB · 0 genes
• Signaling Suppression · 0 genes
• Tissue-protective Macrophage · 0 genes

Intercellular communication (1)

• BMP-ECM Signaling · 0 genes

migration & adhesion (3)

• Actin-mediated Migration · 0 genes
• Desmosomal Adhesion · 0 genes
• Macrophage Identity Adhesion · 0 genes

Mitochondrial & OxPhos (12)

• Colonocyte Metabolic Homeostasis · 0 genes
• Complex I Assembly · 0 genes
• Metabolic Bioenergetics · 0 genes
• Mitochondrial Assembly · 0 genes
• Mitochondrial OxPhos · 0 genes
• Mitochondrial OxPhos · 0 genes
• Mitochondrial OxPhos · 0 genes
• Oxidative Phosphorylation · 0 genes
• OxPhos & Mitochondrial · 0 genes
• OxPhos & Mitochondrial · 0 genes
• OxPhos & Mitochondrial · 0 genes
• OxPhos Complex IV · 0 genes

Protein processing & ER (9)

• ER Cotranslational Processing · 0 genes
• ER Membrane Trafficking · 0 genes
• ER Protein Folding · 0 genes
• ER Protein Homeostasis · 0 genes
• ER Redox Homeostasis · 0 genes
• ER Stress Response · 0 genes
• ER Stress Response · 0 genes
• Proteasome & Apoptosis · 0 genes
• Protein Processing ER · 0 genes

RNA processing & translation (5)

• mRNA Splicing Processing · 0 genes
• Nuclear Transport RNA · 0 genes
• RNA Processing Homeostasis · 0 genes
• RNA Processing Translation · 0 genes
• Translation Initiation · 0 genes

secretory cell development (1)

• Mucosal Restitution Secretory · 0 genes

Stemness (2)

• Intestinal Stem Cell · 0 genes
• Stem-like Regenerative · 0 genes

Stress (13)

• AP-1 Hypoxia Response · 0 genes
• Apoptosis Regulation · 0 genes
• BMP-ID Stress Response · 0 genes
• Chaperone Proteostasis · 0 genes
• Cytokine Feedback Stress · 0 genes
• Growth Arrest Stress · 0 genes
• Heat Shock Response · 0 genes
• Hypoxia Response Regulation · 0 genes
• Immediate Early Stress · 0 genes
• Integrated Stress Response · 0 genes
• Oxidative Stress Response · 0 genes
• Oxidative Stress ROS · 0 genes
• Stress Survival Response · 0 genes

WNT pathway (2)

• WNT Beta-catenin · 0 genes
• WNT-BMP Morphogenic · 0 genes