Inflammatory Activation Stress
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes ENO1 (glycolytic enzyme, also moonlights in transcription/stress), HMGA1 (chromatin architectural protein, oncogenic), SNRPD1 (spliceosome), ENSA (endosulfine, cell cycle/PP2A regulation), S100P (calcium-binding, inflammation/cancer), WFDC2 (WAP domain, epithelial marker), HLA-DRB1 (antigen presentation), PLP2 (proteolipid). The module is upregulated in UC inflammation (delta_inflammation_UC=0.141 sig.). The mix of genes spans chromatin regulation (HMGA1), RNA splicing (SNRPD1), metabolic (ENO1), and immune (HLA-DRB1, S100P) functions. HMGA1 and ENO1 are frequently co-expressed in proliferating or stressed epithelial/macrophage-like cells. S100P and WFDC2 are epithelial stress/inflammation markers. The module does not cleanly fit one pathway; the strongest unifying theme across the top genes is a general cellular stress/activation response with chromatin and metabolic reprogramming components. Given the UC inflammation association and the mix of HMGA1, ENO1, S100P, HLA-DRB1, this most closely resembles an inflammatory activation/stress program in M-like cells.
Genes
Most correlated modules
- Antigen Presentation Housekeeping · correlation 0.99
- RNA Processing Homeostasis · correlation 0.99
- ER Protein Homeostasis · correlation 0.98
- Interferon Antigen Processing · correlation 0.98
- Housekeeping Mixed · correlation 0.98
- OxPhos & Mitochondrial · correlation 0.98
- Oxidative Stress Response · correlation 0.97
- Mitochondrial OxPhos · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.