Cytokine Feedback Stress
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
SOCS1 (JAK-STAT negative regulator), GADD45B (NF-κB-induced stress/DNA damage response gene), and RND3 (stress-induced Rho GTPase) anchor this module as a cytokine-feedback and cellular stress response program. AMD1 links to polyamine metabolism under stress. TLE4 and INTS6 contribute transcriptional repression. As a topological neighbor of M87 (inflammatory activation), this module likely represents the counter-regulatory response to cytokine signaling — consistent with its upregulation in CD inflammation but with negative treatment response, suggesting it reflects active disease-state stress rather than resolution.
Genes
Most correlated modules
- NF-κB Inflammatory Response · correlation 0.89
- Macrophage Oxidative Complement · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.