Macrophage Oxidative Complement
Gene co-expression module in Microfold-like cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
NCF4 (neutrophil cytosol factor 4) is a component of the NADPH oxidase complex, expressed in macrophages and neutrophils. CFD (complement factor D/adipsin) is a serine protease of the alternative complement pathway. POLD1 encodes DNA polymerase delta involved in DNA repair. RASAL1 is a RAS GTPase-activating protein. PPFIBP2 is a focal adhesion scaffold. The module is significantly upregulated in CD inflammation. The combination of NCF4 and CFD suggests a macrophage/innate immune oxidative and complement program, though the module is heterogeneous. NABP1 (ssDNA binding) and POLD1 may reflect DNA damage response co-activation.
Genes
Most correlated modules
- Complement Macrophage Activation · correlation 0.95
- Oxidative Stress ROS · correlation 0.93
- NF-κB Inflammatory Response · correlation 0.83
- Cytokine Feedback Stress · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.