Paneth antimicrobial granules
Gene co-expression module in Paneth cells
| Category | Antimicrobial |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
This is the canonical Paneth cell granule antimicrobial repertoire: DEFA5, DEFA6, LYZ, PLA2G2A, REG3A, REG1B, ITLN2, PRSS2 (trypsin, which activates DEFA5), LCN2. It also includes SERPINA1, GUCA2A, and the ER chaperone HSPA5 supporting high secretory load. This is the core Paneth identity and effector program.
Genes
Most correlated modules
- ER secretory load · correlation 0.32
- Crypt progenitor-absorptive · correlation 0.25
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.