Paneth cells: gene co-expression modules

Long-lived secretory cells at the small-intestinal crypt base, packed with antimicrobial granules; sensing microbes, they release defensins and lysozyme, and supply Wnt signals to adjacent stem cells.

SCUBA's reference network for Paneth cells holds 25 gene modules covering 225 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

Antimicrobial (1)

• Paneth antimicrobial granules · 0 genes

chromatin regulation & transcription (3)

• Chromatin remodeling · 0 genes
• Chromatin remodeling regulators · 0 genes
• Transcription factor program · 0 genes

Cytoskeletal (1)

• Rho GTPase regulation · 0 genes

Epithelial development (3)

• Crypt progenitor program · 0 genes
• Crypt progenitor-absorptive · 0 genes
• Progenitor-like differentiation · 0 genes

Housekeeping (1)

• Abundant housekeeping transcripts · 0 genes

Mitochondrial & OxPhos (3)

• Electron transport chain · 0 genes
• Mitochondrial biogenesis · 0 genes
• Na/K-ATPase energetic transport · 0 genes

Protein processing & ER (1)

• ER secretory load · 0 genes

RNA processing & translation (3)

• hnRNP mRNA processing · 0 genes
• Translation elongation · 0 genes
• Translation machinery · 0 genes

Secretion (4)

• Cholinergic secretory signaling · 0 genes
• Granule transport · 0 genes
• Regulated granule exocytosis · 0 genes
• Vesicle trafficking · 0 genes

Stem cell niche (1)

• LGR5+ crypt stemness · 0 genes

Stress (2)

• Chaperone proteostasis stress · 0 genes
• Redox homeostasis · 0 genes

Technical artifact (2)

• Long-gene nuclear transcripts · 0 genes
• Long-gene nuclear transcripts · 0 genes