ER secretory load
Gene co-expression module in Paneth cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Several genes are ER translocation and folding machinery (CALR, PPIB, SSR4, SEC61B). Others are MHC class I components (HLA-C, B2M) together with secreted products (CST3, TFF3, REG1A). This indicates a secretory ER load program supporting secretion of antimicrobial and secreted proteins and MHC-I loading.
Genes
Most correlated modules
- Redox homeostasis · correlation 0.85
- Electron transport chain · correlation 0.82
- Translation machinery · correlation 0.82
- Translation elongation · correlation 0.79
- Abundant housekeeping transcripts · correlation 0.76
- Progenitor-like differentiation · correlation 0.69
- Mitochondrial biogenesis · correlation 0.59
- Chaperone proteostasis stress · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.