Colonocyte Senescence
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Multiple genes are enriched in senescent colonocytes (PRDX6, FTH1, RIMKLA per top subsets). Hub genes PDCD4 (programmed cell death 4, translation repressor and tumor suppressor associated with growth arrest) and FOXN3 (transcription factor with tumor suppressor/growth arrest roles) support a senescence/growth arrest program. IP6K2 promotes apoptosis, GPX4 protects against ferroptosis (relevant in senescent cells with iron accumulation), FTH1 (ferritin, iron sequestration), OXR1 (oxidative stress resistance), PRDX6 (antioxidant). ACADM and FCGRT are metabolic/immune. The module is significantly decreased in inflammation, consistent with loss of differentiated/senescent colonocytes during active disease. The oxidative stress resistance and iron metabolism genes alongside senescence markers define this as a senescent colonocyte program.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.80
- Fatty Acid Oxidation · correlation 0.75
- Nuclear Receptor Signaling · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.