Mitochondrial OxPhos
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 22 genes have a known function matching the annotation |
Why this annotation
Top hub genes are predominantly mitochondrial: SLC25A5 (ANT2, ADP/ATP translocator), VDAC1 (outer membrane voltage-dependent anion channel), SLC25A3 (mitochondrial phosphate carrier), GHITM (mitochondrial morphology), SDHD (succinate dehydrogenase subunit D), ACO2 (aconitase 2, TCA cycle), ETHE1 (mitochondrial persulfide dioxygenase), MPST and TST (sulfur metabolism, mitochondrial). Module is significantly decreased in CD inflammation and restored by CD treatment, consistent with mitochondrial dysfunction in IBD. Neighbor to M45 (fatty acid oxidation), sharing the mitochondrial metabolic theme.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.85
- ER-Golgi Trafficking · correlation 0.81
- Arp2/3 Actin Branching · correlation 0.80
- Colonocyte Senescence · correlation 0.80
- Ubiquitin Signaling Response · correlation 0.80
- Fatty Acid Oxidation · correlation 0.79
- PPARG Lipid Metabolism · correlation 0.78
- Glycosylation & Membrane · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.