BMP-ECM Fibroblast
Gene co-expression module in Fibroblasts
| Category | ECM remodeling |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub gene ACVRL1 (ALK1, TGF-beta/BMP receptor, expressed in endothelial and stromal cells), VCAN (versican, large ECM proteoglycan), LAMA2 (laminin alpha-2, basement membrane), ITGB5 (integrin beta-5, ECM adhesion), MRC2 (mannose receptor C-type 2/ENDO180, collagen endocytosis), CLEC11A (stem cell factor/LSLCL, bone marrow stromal), GNG11 (G-protein subunit), and TFPI (tissue factor pathway inhibitor, anticoagulant) define a program combining ECM/basement membrane production with TGF-beta/BMP signaling. ACVRL1 and LAMA2 together suggest a pericyte-like or vascular-associated fibroblast state. MRC2 is involved in collagen turnover. The module is a neighbor to M18 and M65, consistent with ECM-producing fibroblast states. The combination of ACVRL1 (BMP/TGF-beta receptor), VCAN, LAMA2, and ITGB5 suggests a matrix-remodeling fibroblast with BMP signaling activity.
Genes
ACVRL1, CLEC11A, GNG11, ITGB5, LAMA2, MRC2, TFPI, VCAN
Most correlated modules
- Homeostatic Fibroblast Identity · correlation 0.76
- CCL11 Secretory Fibroblast · correlation 0.75
- Microfibril ECM Fibroblast · correlation 0.69
- Subepithelial Fibroblast · correlation 0.69
- Elastic Fiber ECM · correlation 0.68
- TGF-beta ECM Regulation · correlation 0.66
- Stromal Niche Signaling · correlation 0.65
- Interferon Response · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.