MHC-II Antigen Presentation
Gene co-expression module in Gamma-delta T cells
| Category | Immune regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
The module is dominated by MHC class II genes (HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, HLA-DRA, HLA-DMA, HLA-DMB, HLA-DRB5, HLA-DQA2, HLA-DPB1) plus CD74 (MHC-II invariant chain chaperone), forming a complete antigen presentation complex. This represents MHC class II antigen presentation machinery, which can be expressed by activated γδ T cells with antigen-presenting capacity.
Genes
CD74, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB5, PLPP5
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.