PLPP5 — Phospholipid phosphatase 5
PLPP5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLPP5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B cell B cell maturation | ABCB1, ABCB4, BTLA, C1orf162, CD200, COL19A1, DSP, FCER2 +15 more | View in SCUBA |
| Gamma-delta T cells | MHC-II Antigen Presentation Immune regulation | CD74, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1 +3 more | |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ACLY, ASPH, C9orf152, CKAP4, ESRP1, FABP2, IL13RA1, RAB2A +8 more | View in SCUBA |
About the gene
| Synonyms | DPPL1, HTPAP, PPAPDC1B |
|---|---|
| Chromosome | 8: 38263130-38269243 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid metabolism |
Function
Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.