HLA-DMA — Major histocompatibility complex, class II, DM alpha

HLA-DMA belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HLA-DMA's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	MHC-II antigen presentation B cell maturation	CD53, CD81, CYTH1, DAPP1, DNAJC10, FAM3C, FCRLA, GPR18 +11 more	View in SCUBA
CD8⁺ T cells	MHC Class II Presentation Immune regulation	CD74, COTL1, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA +3 more	View in SCUBA
Endothelial	MHC Class II Presentation Inflammation	CD74, CIITA, CST3, GSTK1, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1 +7 more	View in SCUBA
Gamma-delta T cells	MHC-II Antigen Presentation Immune regulation	CD74, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA +3 more
Glial cells	MHC-II Antigen Presentation Inflammation	C2, CD74, CIITA, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA1 +3 more	View in SCUBA
Goblet cells	MHC Class II Antigen Presentation Immune function	C2, CD74, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB5 +2 more	View in SCUBA
Macrophages	MHC-II Antigen Presentation Innate immunity	AIF1, B2M, C1QA, C1QB, C1QC, CD68, CD74, CST3 +19 more	View in SCUBA
Monocytes	MHC-II Antigen Presentation Innate immunity	HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, PEA15 +1 more	View in SCUBA
Pericytes	MHC-II Antigen Presentation Inflammatory	CD74, CIITA, CYYR1, FLI1, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQB1 +4 more	View in SCUBA

About the gene

Synonyms	D6S222E, RING6
Chromosome	6: 32948613-32969094
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Biological process	Adaptive immunity, Immunity

Function

Plays a critical role in catalyzing the release of class II- associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.