Lipid-Metabolic Homeostasis
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes span lipid metabolism (PIP4K2C, ACER3), glutathione/detox (GSTK1), vesicle trafficking (RABGGTB), calcium/Golgi homeostasis (NUCB1), and stress response (TRAP1). No single tight pathway dominates; the module reflects general cellular metabolic homeostasis with lipid and vesicle components. Uniform expression across subsets and moderate coherence support a housekeeping classification. Upregulation in CD inflammation (delta_inflammation_CD sig.) may reflect metabolic adaptation.
Genes
Most correlated modules
- Purinergic Receptor Signaling · correlation 0.86
- Innate Immune Sensing · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.