Innate Immune Sensing
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 23 genes have a known function matching the annotation |
Why this annotation
Top hub genes include RIGI (RIG-I, cytosolic dsRNA sensor and master antiviral innate immune receptor), SHFL (antiviral restriction factor C19orf66), PRKRIP1 (PKR-interacting protein 1, antiviral), NOD1 (cytosolic bacterial peptidoglycan sensor), TDRD7 (Tudor domain RNA granule component with antiviral function), ATRIP (ATR-interacting protein, DNA damage sensing), and STIMATE (STIM-activating enhancer, calcium signaling). CCL28 is a chemokine. The module is strongly upregulated in UC inflammation and reversed in remission. The combination of RIG-I, SHFL, PRKRIP1, NOD1, and TDRD7 defines a pattern recognition/antiviral innate immune sensing program. This is a neighbor to the canonical ISG modules (M143, M145) and likely represents the upstream sensing/signaling arm of the interferon response.
Genes
Most correlated modules
- ISG Regulatory Program · correlation 0.90
- Purinergic Receptor Signaling · correlation 0.85
- Type I Interferon · correlation 0.84
- Aminoacyl-tRNA Synthetase · correlation 0.80
- Lipid-Metabolic Homeostasis · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.