Purinergic Receptor Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 24 genes have a known function matching the annotation |
Why this annotation
ADORA3 (adenosine A3 receptor) is a canonical mast cell surface receptor mediating degranulation and cytokine release upon adenosine stimulation. ST3GAL1 (sialyltransferase) contributes to glycan remodeling on mast cell surface. IGF2R and RAB11B reflect lysosomal/endosomal trafficking relevant to granule recycling. THEMIS2 and LY75 are immune cell signaling/endocytic receptors. GPAT3 and FADS3 reflect lipid metabolism. The module captures a mast cell identity/receptor signaling state centered on ADORA3-mediated purinergic signaling and membrane trafficking.
Genes
Most correlated modules
- Calcium Store Signaling · correlation 0.91
- Inflammatory IRAK3-BATF Response · correlation 0.90
- Cytoskeletal Remodeling · correlation 0.87
- ISG Regulatory Program · correlation 0.87
- Cytoskeletal Trafficking · correlation 0.87
- Lipid-Metabolic Homeostasis · correlation 0.86
- Innate Immune Sensing · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.