Mast Cell Immune Identity
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 31 genes have a known function matching the annotation |
Why this annotation
This 31-gene module has moderate expression (~23% positive) and no strong disease association. Key hub genes include SMAD7 (TGF-β signaling inhibitor, core member), SASH3 (SH3 domain scaffold, immune signaling, core), MLLT1 (ENL, transcriptional elongation, core), C3AR1 (complement C3a receptor, mast cell activation marker, core), VPS41 (lysosomal biogenesis, core), ITGAM (CD11b/Mac-1, integrin, core), RASGRP4 (RasGRP4, mast cell-specific Ras GEF), TCAF1 (TRPA1 regulator), SEMA7A (semaphorin, immune regulation), SNAI3 (Snail family transcription factor). C3AR1, RASGRP4, ITGAM, and SASH3 are all relevant to mast cell identity and immune signaling. SMAD7 inhibits TGF-β. The module appears to represent a mast cell immune regulatory/identity program with complement receptor signaling.
Genes
Most correlated modules
- Actin Cytoskeleton Remodeling · correlation 0.69
- Cytoskeletal Signaling · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.