Cytoskeletal Signaling
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes GRAP2 (immune receptor adaptor linking to cytoskeleton), LASP1 (LIM and SH3 actin-binding protein), CAP1 (cyclase-associated protein, actin dynamics), ARHGEF6 (Rac/Cdc42 GEF, cytoskeletal signaling), PTPN6 (SHP-1 phosphatase, immune signaling), BICD2 (dynein adaptor, vesicle transport) define a cytoskeletal signaling program. Additional members ATP6V0A2 (vacuolar ATPase), ALS2 (Rho GEF), AP3D1 (adaptor protein complex-3, vesicle trafficking), ZNRF1 (E3 ligase at membrane) support cytoskeletal/membrane organization. GSR and GLRX2 are peripheral redox genes. The dominant program is actin cytoskeletal regulation with immune signaling adaptors, consistent with mast cell morphology and receptor-coupled cytoskeletal remodeling.
Genes
Most correlated modules
- Actin Cytoskeleton Remodeling · correlation 0.75
- Mast Cell Immune Identity · correlation 0.66
- Immune Checkpoint State · correlation 0.65
- Mitochondrial Maintenance · correlation 0.62
- Mast Cell Signaling · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.