Actin Cytoskeleton Remodeling
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes MSN (moesin, ERM protein linking actin to plasma membrane), DOCK11 (Rho GEF for Cdc42/Rac), ESYT1 (extended synaptotagmin, ER-plasma membrane tethering/lipid transfer), CAPN1 (calpain-1, calcium-dependent actin remodeling protease), LPIN1 (phosphatidic acid phosphatase/lipid metabolism), ARHGAP30 (Rho GAP), TLN1 (talin, integrin-actin linker), ACTN4 (alpha-actinin-4), GSN (gelsolin, actin filament severing), FHOD1 (formin), CCDC88B (GEF/scaffold) all converge on actin cytoskeleton remodeling and membrane-cytoskeleton linkage. OSBPL8 adds lipid transfer at membrane contact sites. This is a coherent cytoskeletal/actin remodeling module relevant to mast cell migration and morphology.
Genes
Most correlated modules
- Cytoskeletal Signaling · correlation 0.75
- Immune Checkpoint State · correlation 0.74
- Mast Cell Signaling · correlation 0.73
- Actin-driven Migration · correlation 0.70
- Mast Cell Immune Identity · correlation 0.69
- Mitochondrial Maintenance · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.