Mast Cell Migration
Gene co-expression module in Mast cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes LRCH3 and LRCH1 (leucine-rich repeats and calponin homology domain proteins) regulate immune cell migration and cytoskeletal organization. ACIN1 (apoptotic chromatin condensation inducer in the nucleus) links to apoptotic chromatin remodeling. SYTL2 (synaptotagmin-like protein 2, Rab27 effector) is directly implicated in mast cell degranulation and secretory lysosome trafficking. CUX1 (transcription factor, cell cycle/differentiation), UBR2/UBR1 (N-end rule E3 ubiquitin ligases, protein quality control), MED1 (Mediator coactivator), UPF1 (NMD helicase), TNRC18 (chromatin), ZNF148 (transcription factor), NXPE3 (neurexophilin), MAN1A1 (Golgi mannosidase), ABHD6 (lipase), MR1 (MHC-related antigen presentation), ABCC4 (ABC transporter, prostaglandin export). SYTL2 and ABCC4 are notable mast cell functional genes. The module is mixed but LRCH proteins and SYTL2 suggest a mast cell migration/degranulation regulatory program.
Genes
Most correlated modules
- Mast Cell Activation Signaling · correlation 0.78
- Actin-driven Migration · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.