Actin-driven Migration
Gene co-expression module in Mast cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 21 genes have a known function matching the annotation |
Why this annotation
This 21-gene module shows a striking positive delta_inflammation_UC (0.760, though n.s.) and negative delta_remission_UC (−0.495), suggesting upregulation in UC inflammation. Hub genes include FMNL2 (formin-like 2, actin polymerization/cell migration, core), TGFB1 (TGF-β1, key immunomodulatory cytokine), SPIRE1 (actin nucleator), FYN (Src-family kinase, mast cell signaling), PTK2 (FAK, focal adhesion kinase, migration), EGLN1 (PHD2, HIF prolyl hydroxylase, hypoxia sensing), RHOF (Rho GTPase, filopodia), PLEC (plectin, cytoskeletal linker), FMNL3 (formin-like 3, actin), RIPOR1 (actin/migration), STAT3 (transcription factor, cytokine signaling), VEGFB (angiogenic factor). The module is dominated by actin cytoskeletal remodeling genes (FMNL2, FMNL3, SPIRE1, RHOF, PLEC, RIPOR1) combined with migration/adhesion kinases (FYN, PTK2) and TGF-β/STAT3 signaling. This represents a mast cell migration and cytoskeletal remodeling program activated in UC inflammation.
Genes
Most correlated modules
- Cytoskeletal Trafficking · correlation 0.83
- Homeostatic Survival Signaling · correlation 0.72
- Mast Cell Migration · correlation 0.71
- Actin Cytoskeleton Remodeling · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.