Mast Cell Activation Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 30 genes have a known function matching the annotation |
Why this annotation
IKZF3 (Aiolos) is a lymphocyte/mast cell transcription factor involved in lineage development. TESPA1 is expressed in thymocytes and mast cells and regulates calcium signaling downstream of antigen receptors. CAMKK1 and PRKCA are calcium/PKC kinases central to mast cell activation signaling. PIK3R6 is a PI3K regulatory subunit involved in immune cell signaling. KLHL6 regulates BCL6 and is involved in lymphocyte biology. CCNL2 is a cyclin involved in transcriptional regulation. The module reflects mast cell activation signaling through calcium/kinase cascades, with developmental transcription factor context.
Genes
Most correlated modules
- Eicosanoid Biosynthesis · correlation 0.88
- Epigenetic Transcriptional Control · correlation 0.87
- Cytoskeletal Trafficking · correlation 0.86
- Endolysosomal Trafficking · correlation 0.82
- Mast Cell Migration · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.