Oxidative Stress Response
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include GRAMD4 (GRAM domain protein involved in apoptosis and lipid sensing), CRISPLD2 (cysteine-rich secretory protein, anti-inflammatory/LPS-binding), FDXR (ferredoxin reductase, mitochondrial ROS production, p53 target gene involved in ferroptosis/oxidative stress), PODXL (podocalyxin, cell adhesion), ARHGAP32 (Rho GTPase-activating protein), FFAR3 (free fatty acid receptor 3, SCFA receptor relevant to colon microbiome signaling), GSTM1 (glutathione S-transferase mu 1, oxidative stress detoxification), FHL1 (LIM domain cytoskeletal protein), TMEM64 (calcium signaling). FDXR and GRAMD4 suggest p53-mediated oxidative stress/apoptosis. GSTM1 supports oxidative detoxification. FFAR3 and CRISPLD2 suggest metabolic/anti-inflammatory context. The module is modestly upregulated in UC inflammation. The combination is heterogeneous but leans toward an oxidative/metabolic stress response in the colon microenvironment.
Genes
Most correlated modules
- MHC-I Antigen Presentation · correlation 0.81
- Chromatin Epigenetic Regulation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.