MHC-I Antigen Presentation
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 28 genes have a known function matching the annotation |
Why this annotation
Key genes include PSMB9 (immunoproteasome beta subunit, ISG), ERAP2 (ER aminopeptidase 2, trims peptides for MHC-I loading), HLA-E and HLA-F (non-classical MHC class I molecules), UBE2L6 (ISG15-conjugating E3 enzyme, ISGylation), PDCD1LG2 (PD-L2, immune checkpoint ligand), APOL3 (innate immunity), TRAF5 (TNF receptor signaling), and NFE2L3 (NF-E2-related transcription factor). PSMB9+ERAP2+HLA-E+HLA-F constitute a coherent MHC class I antigen processing and presentation pathway. UBE2L6 links to ISGylation. The module is strongly upregulated in UC inflammation and reversed in remission, consistent with interferon-gamma-driven immunoproteasome and antigen presentation induction. Neighbor to M143 which also contains TAP2 and NLRC5, reinforcing the antigen presentation theme.
Genes
Most correlated modules
- Oxidative Stress Response · correlation 0.81
- Type I Interferon · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.