Chromatin Epigenetic Regulation
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
This module has lower mean expression (0.532) and detection rate (37.2%). Hub genes include ZC2HC1A (zinc finger CCHC-type and RRM domain, RNA binding/regulation), RNF146 (E3 ubiquitin ligase, Tankyrase substrate, Wnt signaling), TBC1D32 (TBC domain Rab GAP, ciliogenesis/vesicle trafficking), KAT6B (lysine acetyltransferase 6B, histone H3K9 acetyltransferase, chromatin regulation), MRPL49 (mitochondrial ribosomal protein), SCAPER (S-phase cyclin A-associated protein in the ER, cell cycle), PCGF1 (polycomb group RING finger 1, PRC1 complex, chromatin silencing), SUPT3H (SPT3 homolog, SAGA complex, transcription), IDI1 (isopentenyl-diphosphate delta isomerase 1, cholesterol/isoprenoid synthesis), ANKRD36B (ankyrin repeat domain), BLCAP (bladder cancer-associated protein, tumor suppressor), DRG1 (developmentally regulated GTP-binding protein), EDRF1 (erythroid differentiation regulatory factor), EMC2 (ER membrane complex subunit), PDP1 (pyruvate dehydrogenase phosphatase), MPV17L2 (mitochondrial inner membrane protein), SOD2 (superoxide dismutase 2, mitochondrial antioxidant). The dominant theme across hub genes is chromatin/epigenetic regulation: KAT6B (histone acetyltransferase), PCGF1 (PRC1 polycomb), SUPT3H (SAGA complex), RNF146 (ubiquitin ligase affecting chromatin). SCAPER links to cell cycle. SOD2 and MPV17L2 suggest mitochondrial stress. This module appears to represent a chromatin/epigenetic regulatory program, possibly related to mast cell differentiation state or stress-induced transcriptional reprogramming.
Genes
Most correlated modules
- mTOR-Cytoskeletal Regulation · correlation 0.83
- RNA Decay Regulation · correlation 0.80
- Oxidative Stress Response · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.