Type I Interferon
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes are canonical interferon-stimulated genes and regulators: IRF9 (component of ISGF3 transcription complex, master ISG regulator), TRIM22 (ISG/antiviral E3 ubiquitin ligase), DDX60L (antiviral RNA helicase), TAP2 (transporter associated with antigen processing, MHC-I pathway), GBP2 (guanylate binding protein, ISG), ZBP1 (Z-DNA/RNA sensor, innate immune), APOL1/APOL2 (innate immunity), HERC5/HERC6 (ISGylation E3 ligases), STAT1 (master transcription factor for ISG induction), NLRC5 (MHC-I transactivator), BST2/tetherin (ISG antiviral), TRAFD1 (innate immune signaling). IRF9+STAT1 form the ISGF3 complex. NLRC5+TAP2 link to MHC-I. This is a Type I/II interferon-driven ISG module with antigen presentation overlap, upregulated in both UC and CD inflammation.
Genes
Most correlated modules
- Type I Interferon · correlation 0.86
- Innate Immune Sensing · correlation 0.84
- MHC-I Antigen Presentation · correlation 0.74
- Innate Immune Regulation · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.