Homeostatic Survival Signaling
Gene co-expression module in Mast cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
This module is notable for a significant negative delta_inflammation_UC (−0.315, sig.), meaning it is downregulated in UC inflammation, and recovers in remission (+0.198). Hub genes include GBE1 (glycogen branching enzyme, glycogen metabolism), INTS11 (integrator complex endonuclease, RNA Pol II snRNA processing), SCFD2 (Sec1/Munc18 family, vesicle docking), DNASE2 (lysosomal DNase, DNA degradation/autophagy), SGK1 (serum/glucocorticoid-regulated kinase, stress/survival signaling), SCAMP2 (secretory carrier membrane protein, vesicle trafficking), SNX25 (sorting nexin, endosomal sorting), MINPP1 (inositol polyphosphate phosphatase), ARL11 (Arf-like GTPase, apoptosis/immune regulation), ARHGAP31 (Rho GAP), AGAP1 (Arf GAP), FMN1 (formin, actin nucleation). SGK1 is a key stress/survival kinase regulated by glucocorticoids and PI3K. The combination of SGK1, DNASE2, ARL11, and vesicle trafficking genes in a module downregulated during UC inflammation suggests a homeostatic/survival program suppressed during active inflammation.
Genes
Most correlated modules
- Actin-driven Migration · correlation 0.72
- Mast Cell Signaling · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.