Mast Cell Signaling
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes include GPR34 (lysophosphatidylserine receptor highly expressed in mast cells), CD9 (tetraspanin mast cell marker), RAC2 (Rho GTPase critical for mast cell migration and signaling), CTSD (cathepsin D, lysosomal protease in mast cell granules), PROS1 (protein S, anticoagulant secreted by mast cells), NDRG2 (stress/differentiation), and CALHM2 (calcium homeostasis). PMP22 is expressed in mast cells beyond its myelin role. This module reflects mast cell signaling, lysosomal function, and identity. Neighbor context with M88 (FCER1G/HPGDS) and M50 (SIGLEC8/LTC4S) supports mast cell identity cluster.
Genes
Most correlated modules
- Mitochondrial Maintenance · correlation 0.78
- Actin Cytoskeleton Remodeling · correlation 0.73
- Immune Checkpoint State · correlation 0.71
- Mast Cell Identity · correlation 0.70
- Leukotriene Biosynthesis · correlation 0.64
- Cytoskeletal Signaling · correlation 0.60
- Inflammatory Activation · correlation 0.57
- Homeostatic Survival Signaling · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.