Innate Immune Regulation
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Top hub TRIM56 is an E3 ubiquitin ligase with established roles in innate antiviral immunity (promotes STING/cGAS signaling, restricts RNA viruses). GBP3 (guanylate-binding protein) is an interferon-stimulated gene involved in innate immunity and inflammasome regulation. BRD8 (bromodomain chromatin reader), CHST12 (chondroitin sulfotransferase, glycosaminoglycan biosynthesis relevant to mast cell granule matrix), SLC39A10 (zinc importer, immune cell function), NUMB (Notch/cell fate), CDC16 (APC/C ubiquitin ligase complex), UFL1 (UFMylation, ER stress/UPR), STT3B (N-glycosylation, ER), PRKAR2A (PKA-RIIα, cAMP signaling), AKAP10 (AKAP, PKA anchoring), PGS1 (phosphatidylglycerol synthase). The module combines innate immune sensing (TRIM56, GBP3) with regulatory/housekeeping functions. The significant negative delta_treatment_CD suggests disease-relevant regulation.
Genes
Most correlated modules
- Intracellular Trafficking · correlation 0.70
- Type I Interferon · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.