Intracellular Trafficking
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
This module has 14 genes with uniform low-moderate expression (~18% positive). Hub genes include SLC4A7 (sodium bicarbonate cotransporter, ion transport), KDM5B (histone H3K4 demethylase, chromatin regulation), SMCR8 (C9orf72 complex, autophagy/lysosome regulation), ARHGAP25 (Rho GTPase-activating protein, cytoskeletal regulation), TNPO1 (transportin-1, nuclear import), CSNK2A1 (casein kinase 2, broad signaling), LTN1 (E3 ubiquitin ligase, ribosome quality control), and DENND1B (DENN domain, Rab GTPase regulation). The module lacks a tight functional theme. SMCR8 and DENND1B relate to vesicle/endosomal trafficking; KDM5B to chromatin; TNPO1 to nuclear transport. The most coherent thread across several genes is intracellular trafficking and regulatory signaling. Given the neighbor context of other heterogeneous low-expression modules, this likely represents a loosely co-expressed housekeeping/regulatory program.
Genes
Most correlated modules
- Chromatin & Ubiquitin Regulation · correlation 0.78
- Immune Activation Signaling · correlation 0.78
- UPR Secretory Stress · correlation 0.71
- Innate Immune Regulation · correlation 0.70
- DNA Damage Response · correlation 0.69
- Chromatin Epigenetic Regulation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.