Monocyte-Macrophage Differentiation
Gene co-expression module in Monocytes
| Category | Developmental |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
RUNX3 is the top hub gene and a key transcription factor for tissue-resident myeloid cell differentiation and monocyte-to-macrophage transition. ADGRE2 and ADGRE3 (EGF-like module adhesion GPCRs) are expressed on monocytes/macrophages and regulate tissue residency. NRARP and HES4 are Notch pathway targets that regulate myeloid differentiation. CYSLTR2 (cysteinyl leukotriene receptor 2) is expressed on inflammatory monocytes. TGM2 (transglutaminase 2) is a marker of monocyte-to-macrophage differentiation and tissue remodeling. RASSF5 regulates integrin-mediated adhesion. BID links to apoptosis regulation during differentiation. This module represents a Notch/RUNX3-driven monocyte differentiation toward tissue-resident macrophage identity.
Genes
ADGRE2, ADGRE3, BID, CYSLTR2, FAM110A, HES4, MARCKSL1, NRARP, PRELID1, RASSF5, RUNX3, SFMBT2, TGM2
Most correlated modules
- MHC-II Antigen Presentation · correlation 0.83
- Inflammatory Stress Response · correlation 0.75
- Inflammasome Activation · correlation 0.75
- NR4A Immediate-Early · correlation 0.72
- ER Stress Response · correlation 0.70
- Epigenetic Inflammatory Reprogramming · correlation 0.69
- Fc Receptor Activation · correlation 0.68
- AP-1 Stress Response · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.