Endosomal Sorting
Gene co-expression module in Monocytes
| Category | Vesicular traficking |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
HGS (Hrs, ESCRT-0 component for endosomal sorting), GGA2 (Golgi-to-endosome vesicle trafficking), PIK3R5 (PI3K regulatory subunit enriched in endosomal/phagocytic signaling), SSH1 (slingshot phosphatase regulating actin/endocytosis), GAB2 (scaffolding for PI3K/endocytic signaling), and USP12 (deubiquitinase regulating endosomal cargo) collectively define an endosomal sorting and vesicular trafficking program. MAFG may modulate transcriptional responses downstream. Upregulated in IBD inflammation, consistent with enhanced phagocytic/endosomal activity in inflammatory monocytes. Neighbor to M50 (autophagy) and M4 (vesicle fusion), supporting a shared vesicular trafficking neighborhood.
Genes
FPGS, GAB2, GGA2, HGS, MAFG, PIK3R5, SEMA6B, SSH1, TPRA1, USP12
Most correlated modules
- Inflammatory Autophagy · correlation 0.86
- MET Tissue Repair · correlation 0.84
- Innate Immune Transcription · correlation 0.84
- AMPK-FOXO Stress Response · correlation 0.81
- Secretory Vesicle Trafficking · correlation 0.81
- Autophagy Initiation · correlation 0.73
- Myeloid Epigenetic Regulation · correlation 0.68
- G-protein Membrane Remodeling · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.