Heat Shock Response
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
All top hub genes are canonical heat shock proteins: HSPA1A, HSPA1B (HSP70 inducible), HSP90AA1, HSP90AB1 (HSP90 isoforms), HSPH1 (HSP110), HSPE1 (HSP10), HSPD1 (HSP60), HSPA8 (HSC70), DNAJA1/DNAJB1 (HSP40 co-chaperones), CHORDC1 (HSP90 co-chaperone), TCP1 (chaperonin). Core coherence confirms a tight, single biological program. This is the canonical proteotoxic heat shock response. Neighbor to M26 (co-chaperones/BAG3), confirming a heat shock neighborhood.
Genes
CHORDC1, DNAJA1, DNAJB1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPD1, HSPE1, HSPH1, MRPL18, TCP1
Most correlated modules
- Co-chaperone Proteostasis · correlation 0.84
- AP-1 Stress Response · correlation 0.78
- NR4A Immediate-Early · correlation 0.71
- ER Stress Response · correlation 0.67
- ER Stress Response · correlation 0.62
- Monocyte Activation State · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.