Fc Receptor Activation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Top hub CD300E is a myeloid-specific activating receptor that triggers monocyte/macrophage effector functions. FCGR2A (FcγRIIA) mediates phagocytosis and ADCP. LCP2 (SLP-76) is a key signaling adaptor in myeloid activation downstream of Fc receptors. OLR1 (LOX-1) marks inflammatory monocytes and is upregulated in IBD. ARID5A stabilizes IL-6 mRNA, amplifying inflammatory cytokine production. PLSCR1 participates in innate immune signaling. CREM modulates cAMP-dependent immune responses. TRIM25 is an E3 ubiquitin ligase involved in innate immune activation. This module represents Fc-receptor-mediated myeloid activation, strongly upregulated in IBD inflammation.
Genes
ARID5A, CD300E, CREM, FCGR2A, GLUL, LCP2, OLR1, PLSCR1, TRIM25
Most correlated modules
- TNF-driven Activation · correlation 0.93
- Monocyte Immune Tolerance · correlation 0.88
- Epigenetic Inflammatory Reprogramming · correlation 0.84
- IRF1 Innate Activation · correlation 0.81
- NF-κB Signaling · correlation 0.77
- Inflammatory Stress Response · correlation 0.76
- Inflammasome Activation · correlation 0.75
- TREM1 Inflammatory Signaling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.