Quiescent Signaling Regulators
Gene co-expression module in Monocytes
| Category | Tissue homeostasis |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 8 of 22 genes have a known function matching the annotation |
Why this annotation
The genes are mainly transcriptional regulators and signalling modulators: ZFHX3, SSBP3, SERTAD2, DUSP22, MAP3K20, ADCY9, RNF125 and TBC1D9. AHNAK and SCARB1 add membrane and lipid-handling components. There is no single dominant pathway. The pattern suggests a quiescent, homeostatic regulatory state, possibly enriched in more mature or nonclassical-like cells. Confidence is low.
Genes
Most correlated modules
- Lipid-handling maturation · correlation 0.94
- Microtubule organization · correlation 0.89
- Nutrient-sensing autophagy · correlation 0.88
- Tec-kinase Signaling · correlation 0.86
- Golgi Vesicle Trafficking · correlation 0.86
- Classical Monocyte Identity · correlation 0.86
- Iron export metabolism · correlation 0.85
- SYK-Rac actin signaling · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.