Monocyte Innate Surveillance
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
FCN1 (ficolin-1) is a pattern recognition molecule of the lectin complement pathway, highly expressed in classical monocytes and a marker of innate immune surveillance. ICAM3 (CD50) mediates leukocyte-leukocyte adhesion and co-stimulation. MMP25 (MT6-MMP) is a neutrophil/monocyte membrane metalloproteinase involved in ECM remodeling and leukocyte migration. TUBA4A (tubulin alpha-4A) supports cytoskeletal dynamics. RPH3A (rabphilin-3A) is involved in vesicle docking/exocytosis. S100P is a calcium-binding alarmin. PADI2 (peptidylarginine deiminase 2) citrullinates proteins during NETosis and inflammation. CDKN2D (p19, CDK inhibitor) may reflect cell cycle arrest in activated monocytes. The combination of FCN1, ICAM3, MMP25, and PADI2 points to a monocyte innate surveillance and tissue-invasive program, decreased in remission.
Genes
CDKN2D, FCN1, ICAM3, MMP25, PADI2, RPH3A, S100P, TESC, TUBA4A
Most correlated modules
- Leukotriene-Alarmin Response · correlation 0.78
- Classical Monocyte Trafficking · correlation 0.76
- Pentose Phosphate Pathway · correlation 0.70
- Granulocytic Differentiation · correlation 0.70
- BPI Antibacterial Response · correlation 0.67
- Myeloid Activation · correlation 0.63
- Classical Monocyte Activation · correlation 0.63
- p38 MAPK Signaling · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.