Monocyte Tissue Infiltration
Gene co-expression module in Monocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes NRP1 and NRP2 (neuropilins) are co-receptors for semaphorins and VEGF that regulate monocyte migration and tissue infiltration. PMP22 is expressed in monocytes as a growth-arrest/differentiation gene. FPR3 is a formyl peptide receptor driving chemotaxis. PLAU (urokinase) enables extracellular matrix degradation for tissue invasion. RGS1 modulates chemokine receptor signaling. CDCP1 promotes cell migration. SPRED1 regulates RAS/MAPK downstream of growth factor receptors. CD59 protects from complement. The module collectively represents a monocyte tissue infiltration and migration program, strongly upregulated in IBD inflammation. NRP1 also marks immunosuppressive monocytes in inflammatory contexts.
Genes
CD59, CDCP1, FPR3, NRP1, NRP2, PDE4DIP, PLAU, PMP22, PTMS, RGS1, SPRED1, TMEM273
Most correlated modules
- ER Stress Response · correlation 0.81
- Tolerogenic Monocyte Activation · correlation 0.79
- MHC-II Antigen Presentation · correlation 0.76
- Inflammatory Stress Response · correlation 0.74
- Tissue-destructive Macrophage · correlation 0.71
- SPP1+ Inflammatory Macrophage · correlation 0.71
- IFN-γ Monocyte Response · correlation 0.69
- Epigenetic Inflammatory Reprogramming · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.